U=U is defined as achieving and maintaining an undetectable viral load for at least 6 months to prevent sexual transmission of HIV to their partners.¹

What do the DHHS guidelines say about achieving durable viral suppression?

An easy-to-adhere-to and effective ARV regimen with an appropriate safety and tolerability profile may help achieve sustained virologic suppression¹

• Durable viral suppression improves immune function and confers substantial clinical benefits, lowers the risk of both AIDS-defining and non–AIDS-defining complications, and allows people with HIV to have a life expectancy approaching that of people without HIV
• The Panel on Antiretroviral Guidelines for Adults and Adolescents recommends initiating ART immediately (or as soon as possible) after HIV diagnosis in order to increase the uptake of ART and linkage to care, decrease the time to viral suppression for individual patients, and improve the rate of virologic suppression among people with HIV
• To improve and maintain immunologic function and maintain viral suppression, ART should be continued indefinitely without interruption

Predictors of successful virologic suppression¹:

• Low baseline viremia
• High potency of the antiretroviral regimen
• Tolerability of the regimen
• Convenience of the regimen
• Excellent adherence to the regimen